A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.

Nat Commun · 2022 · PMC9551036 · PMID 36216795

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showed a trendno p-value reported

Conformational ensembles from simulations indeed showed a trend towards collapsed structures with lower radius of gyration leading to lower free energies for ACBI2 (Supplementary Data 6 ).

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