Differential modulation of lung aquaporins among other pathophysiological markers in acute (Cl<sub>2</sub> gas) and chronic (carbon nanoparticles, cigarette smoke) respiratory toxicity mouse models.

Front Physiol · 2022 · PMC9554232 · PMID 36246134

Europe PMC DOI

hedged sentences

0.0030

closest p · 0.1× alpha

0.2000

boldest claim

The sentences

highly significantp = 0.003actually significant

SP-A and MUC5B expression showed a decreasing pattern across all toxicity models except the acute Cl 2 toxicity model, which showed a highly significant upregulation of MUC5B (25.95-fold; p = 0.003).

also in 132,142 other papers

did not reach statistical significancep > 0.2not close (p > 0.1)

AQP3 showed significant upregulation in CNT toxicity model (3.83-fold, p = 0.044), unlike the other models which did not reach statistical significance (Cl 2 9.73-fold, p > 0.2, CNT + CSE = 3.93 fold, p = 0.106 and CSE 3.77-fold, p > 0.2), implying its differential responsiveness to CNT exposure.

also in 111,027 other papers

a decreasing trendno p-value reported

A decreasing trend in MUC5B expression was also observed in chronic particulate toxicity models (CNT and CNT + CSE), though it was statistically insignificant.

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.