Control of HIV-1 Replication by CD8⁺ T Cells Specific for Two Novel Pol Protective Epitopes in HIV-1 Subtype A/E Infection.

Responders with the Pol266I mutation showed a trend toward a lower pVL than that of nonresponders, whereas no significant difference in pVL was found between responders harboring Pol266I and those with the WT sequence ( Fig. 8C ), implying that PolTY9-specific T cells might suppress the replication of Pol266I mutant virus in HLA-B*15:02 + individuals infected with the Pol266I mutant virus.

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