Along with the increase in GRS, we noted a significant trend of decrease in BH4, BH4/BH2, and BH4/total biopterin and increase in C-reactive protein and eGFR, but insignificant changes in BH2 ( Fig. 2 A–D ) (Supplementary Table 4, http://links.lww.com/CCM/H178 ).
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Stress Hyperphenylalaninemia Is Associated With Mortality in Cardiac ICU: Clinical Factors, Genetic Variants, and Pteridines.
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