The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function.

Although RNA-seq, ATAC-seq, and flow cytometry all showed a trend for the downregulation of TCF1, it is still unknown how TCF1 is regulated by Bach2.

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As noted above, despite superficial similarities between the NK cell and CD8 KO phenotype, the lack of difference in BATF and Blimp1 expression within KO NK cells argues that there may be significant mechanistic differences in how BACH2 operates within these two cell types.

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