A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand.

Due to low available sample sizes, all the analyses of de novo mutations in mother-offspring pairs were only suggestive but consistently showed a trend of an increased fraction of A H > G H with oocyte age ( Supplementary Material S1.2 ).

also in 53,322 other papers

Our specific analyses, which focused on uncovering a potential interaction between TSSS and generation length indeed showed a positive trend, suggesting that mammals with high generation length demonstrate a faster decrease in A H and increase in G H along the genome ( Supplementary Figure S14 , the same effect is visible on Figure 3B ).

also in 11,005 other papers