Mendelian gene identification through mouse embryo viability screening.

percentage among the LL (18%) (unadjusted P value = 2.7e−06); most notably, this is the only disease category with a higher percentage of disease genes among the EL compared to ML and LL genes; (3) a higher percentage of skeletal disorder genes is found in ML set, although this association is only nominally significant; and (4) for the remaining disease categories, the frequency of disease genes among the EL genes shows values comparable to baseline or even lower, indicative of depletion of these disease categories among the EL genes (Fig. 3 c, Additional file 2 : Fig.

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