PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages.

J Exp Clin Cancer Res · 2022 · PMC9563506 · PMID 36242053

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a significant trendno p-value reported

We utilized the proteomic analysis to demonstrate that the reduction of PCSK9 expression in colon cancer cells induced differentially expressed proteins that were mainly enriched in cellular and metabolic processes, while level of MIF expression had a significant trend for decline.

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