Anti-Apoptotic c-FLIP Reduces the Anti-Tumour Activity of Chimeric Antigen Receptor T Cells.

Although IL-2 release of Her2CAR-cFLIPp43 CAR T cells was overall slightly higher over three donors, this effect failed to reach statistical significance. c-FLIPp43 protein has been shown to bind with RIP1 protein leading to the activation of NF-κB pathway [ 49 ].

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