Mortality among mine and mill workers exposed to respirable crystalline silica.

Conclusions After nearly seven decades of follow-up, the exposure-response analyses showed no evidence of a positive trend for lung cancer, and limited evidence of a trend for non-malignant respiratory disease, and non-malignant renal disease mortality as a result of cumulative RCS exposure in this occupational cohort. http://dx.doi.org/10.13039/100004343 3M https://orcid.org/0000-0002-1715-9427 Kleinschmidt Sarah E. 3M Company funded this study.

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Moreover, when cumulative RCS exposure was lagged for 15 years, a decreasing trend (p trend = 0.01) in lung cancer mortality risk (HRs = 1.00, 0.75, 1.25, 0.49) was observed.

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This study extended mortality follow-up by 11 years from the initial mortality study which observed a significant trend in non-malignant respiratory disease with cumulative RCS exposure, a lack of any well-defined association with lung cancer and an imprecise and nonsignificant association with non-malignant renal disease [ 21 ].

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