The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement.

Nat Commun · 2022 · PMC9568614 · PMID 36241613

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showed a trendno p-value reported

This FcRn-dependent recycling of anti-biotin IgG1-was blocked in a concentration-dependent manner by both MST-HN molecules, whereas the WT-IgG1 or -Fc fragments showed a trend (not significant) towards blockade when used at 500 nM.

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