A Common Variant in the <i>CDK8</i> Gene Is Associated with Sporadic Pituitary Adenomas in the Portuguese Population: A Case-Control Study.

However, the PCDH15 rs10763170 minor allele (T allele) presented a near-significant association with somatotrophinomas (dominant inheritance model, OR 1.55, 95% CI 1.02–2.35, p = 0.035).

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The NEBL rs2359536 and PCDH15 rs10763170 variants were not associated with the overall risk for the disease, although a borderline significant association was observed between the PCDH15 rs10763170 minor allele (T allele) and somatotrophinomas (dominant model, OR 1.55, 95% CI 1.02–2.35, p = 0.035).

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Although the association with these variants was highly significant in the Han Chinese population, these results have not yet been confirmed in any other population.

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