Green Tea Catechins Modulate Skeletal Development with Effects Dependent on Dose, Time, and Structure in a down Syndrome Mouse Model.

The results showed that craniofacial morphological differences after birth (PD3) were subtle, because untreated WT and TS mice tended to separate in the morphospace created by the between-group principal component analysis (bg-PCA) ( Figure 2 A,D); however, permutation tests based on the Procrustes distances between the mean shapes of WT and TS untreated mice indicated that these facial differences did not reach statistical significance at PD3 ( P exp1 = 0.1908; P exp2 = 0.6037).

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