Endogenous GLP-1 levels play an important role in determining the efficacy of DPP-IV Inhibitors in both prediabetes and type 2 diabetes.

Front Endocrinol (Lausanne) · 2022 · PMC9576919 · PMID 36267570

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did not reach statistical significanceno p-value reported

Linagliptin appeared to improve HOMA-IS, HOMA-β, insulinogenic index and oral disposition index in low GLP-1 prediabetes although the LS-mean changes from baseline in these indices did not reach statistical significance.

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