Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults.

Though cluster 10 was identified as a significant vaccine -induced CD8 Spike-specific T cell cluster ( Figure 6D ), comparative analysis of BCG-RV and BCG-NRV did not reach statistical significance ( Figure 6F ), confirming that BCG revaccination impacted the quality and quantity of vaccine induced Spike-specific CD4+ T-cell responses more significantly than CD8+ T-cell responses.

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