Our QPCR results also showed a trend for reduced expression of Cd163 in quadriceps of Spi1 ‐mutant mice compared to floxed‐control mice at both 12 and 22 months (Figure 1h ).
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Myeloid cell-specific mutation of Spi1 selectively reduces M2-biased macrophage numbers in skeletal muscle, reduces age-related muscle fibrosis and prevents sarcopenia.
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