Barely Significant
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A Randomized Phase 2/3 Study of Ensitrelvir, a Novel Oral SARS-CoV-2 3C-Like Protease Inhibitor, in Japanese Patients with Mild-to-Moderate COVID-19 or Asymptomatic SARS-CoV-2 Infection: Results of the Phase 2a Part.

Antimicrob Agents Chemother · 2022 · PMC9578433 · PMID 36098519

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showed a trendno p-value reported
Patients with mild-to-moderate COVID-19 who were treated with ensitrelvir showed a trend of symptom relief.

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a decreasing trendno p-value reported
The mean total score of the predefined 12 symptoms in patients with mild-to-moderate COVID-19 showed a decreasing trend with time after treatment initiation in all groups ( Fig. 4A ).

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.