Spinal cord magnetic resonance imaging and spectroscopy detect early-stage alterations and disease progression in Friedreich ataxia.

Brain Commun · 2022 · PMC9581897 · PMID 36300142

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

showed a trendP = 0.08so close (0.05 < p ≤ 0.1)

Longitudinally, spinal cord cross-sectional area decreased by 2.4% per year relative to baseline ( P = 4 × 10 −4 ), the ratio tNAA/mIns decreased by 5.8% per year ( P = 0.03), and fractional anisotropy showed a trend to decrease (−3.2% per year, P = 0.08).

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borderline significantno p-value reported

The longitudinal decrease in FA averaged over C3–C6 was borderline significant after correction for multiple testing, but post hoc analysis suggests that FA averaged over C4–C5 could be more precise.

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