Platelets upregulate tumor cell programmed death ligand 1 in an epidermal growth factor receptor-dependent manner in vitro.

Blood Adv · 2022 · PMC9582587 · PMID 35482455

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did not reach statistical significanceno p-value reported

However, pretreatment of platelets with ADAM like, decysin 1 and ADAM10 (enzymes that cleave pro-EGF 1020-1027 to release HMW-EGF) inhibitors chymostatin and GI 254023X decreased platelet-induced tumor cell PD-L1 upregulation but did not reach statistical significance ( supplemental Figure 3 G).

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