Evaluation of allogeneic and autologous membrane-bound IL-21-expanded NK cells for chronic lymphocytic leukemia therapy.

In the absence of antibody targeting, both ND-XNK and NNK showed modest cytotoxicity, and although there is a trend toward increased killing by ND-XNK cells, this did not reach statistical significance at most NK:CLL ratios ( Figure 1 B).

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