CFTR reduces the proliferation of lung adenocarcinoma and is a strong predictor of survival in both smokers and non-smokers.

First, we validated the finding in 246 patients with a history of smoking and found a highly significant association with an almost identical hazard ratio compared to the TCGA RNA-Seq data (logrank P = 0.0021; HR, 0.49; CI 0.3 to 0.78 vs.

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For ovarian cancer, we found a borderline significant association between ABCC12 expression and overall survival for grade 3 tumors (logrank P = 0.048; HR, 1.36; CI 1 to 1.85); however, this association was lost when all cancer grades were considered (logrank P = 0.16; Supplementary Fig. 1).

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Results Across 720 analyzed clinical associations with patient outcomes, 363 were nominally significant of which 29 remained significant after stringent Bonferroni correction.

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