Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment.

The C2B 2 ( MAML3 ) subtype was positively associated with metastatic disease, consistent with the WNT-altered (TCGA) subtype having aggressive clinical features 15 , but did not reach statistical significance (Fisher exact test BH-adj, P-value <0.05) in our analyis (Supplementary Table 1 ).

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