Altered Capacity for H₂S Production during the Spontaneous Differentiation of Caco-2 Cells to Colonocytes Due to Reciprocal Regulation of CBS and SELENBP1.

When compared to spontaneous differentiation, the effects of butyrate-induced differentiation were less pronounced and did not reach statistical significance for the most part: Exposure of proliferating cells to 2 mM butyrate slightly increased SELENBP1 and SQOR protein levels 1.5-fold (by trend) and 2.0-fold (by trend), while spontaneous differentiation resulted in a 3.5-fold increase ( p < 0.01) in SELENBP1 and a 4.4-fold increase ( p < 0.01) in SQOR.

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