highly significantp < 0.0001
A first study including 229 PCOS patients and 150 controls reported a highly significant association of Gln223Arg SNP in the LEPR gene with the development of PCOS ( p < 0.0001) [ 129 ].
A first study including 229 PCOS patients and 150 controls reported a highly significant association of Gln223Arg SNP in the LEPR gene with the development of PCOS ( p < 0.0001) [ 129 ].
Considering the recent studies only, a clear trend towards an observation of elevated leptin serum levels in PCOS patients is emerging.