In our study, the abundance of H19 fragments was 1.4-fold higher in patients than controls, and although this did not reach statistical significance, this fold-change is consistent with previous findings [ 18 , 19 ].
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Identifying Candidate Circulating RNA Markers for Coronary Artery Disease by Deep RNA-Sequencing in Human Plasma.
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There was no evidence that levels of any of the circRNAs differed between patients and controls at the nominal threshold (absolute fold change > 1.2, p < 0.01 after adjustment for multiple comparisons), although two circRNAs were borderline significant ( UBAC2 and CLNS1A, Table 5 ).