Genetic Overlap Analysis Identifies a Shared Etiology between Migraine and Headache with Type 2 Diabetes.

Genes (Basel) · 2022 · PMC9601333 · PMID 36292730

Europe PMC DOI

hedged sentences

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closest p · 1.0× alpha

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boldest claim

The sentences

nominally significantp < 0.05actually significant

Of the 144 SNP subsets examined, 132 demonstrated nominally significant concordant effects (OR > 1 and p < 0.05) across migraine (dataset 1) and T2D (dataset 2), while 141 SNP subsets showed significant concordant effects across headache (dataset 1) and T2D (dataset 2).

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highly significantno p-value reported

LDSC provides an unbiased estimate of r g , which may exceed the range (−1 to 1) when standard errors are large and genetic correlations between studies are highly significant.

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