Integrated Analysis of Cytokine Profiles in Malaria Patients Discloses Selective Upregulation of TGF-β1, β3, and IL-9 in Mild Clinical Presentation.

Further analysis of the expression of TGF-β1, TGF-β3, and IL-9 in mild and severe individual patients showed highly significant positive correlations ( Figure 1 B).

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Notably, IL-27 promotes IL-10 production in Plasmodium -infected mice [ 31 ] and, in our patients, IL-10 and IL-27 expression patterns looked very similar, although their correlation did not reach statistical significance.

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There was also a positive trend for IL-27 and IL-10, but it remained below significance ( Supplementary Figure S3 ).

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