Kidney Cyst Lining Epithelial Cells Are Resistant to Low-Dose Cisplatin-Induced DNA Damage in a Preclinical Model of Autosomal Dominant Polycystic Kidney Disease.

Although there was a trend towards an increase in apoptosis following treatment with AZD0156, there was variability within groups in the number of strong positive staining per cyst and differences did not reach statistical significance ( p = 0.18 in CECs and p = 0.46 in non-cystic tissue) ( Figure 6 c,d).

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