Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: First Demonstration of an Intricate Mechanism.

Int J Mol Sci · 2022 · PMC9604315 · PMID 36293552

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The levels of A20 showed a trend of downregulation with age in ovaries of 3- to 22-month-old rats ( Figure 5 A,D), although levels in 9-, 12-, and 22-month-old rats were slightly downregulated compared with those of 3- and 16-month-old rats.

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