Examining the entire population, we found no significant associations with severe asthma, although those homozygous for minor A allele (AA genotype) showed a trend for significance in females (OR = 1.48 [95% CI = 0.86–2.52]), but not males (OR = 0.87 [95% CI = 0.46–1.63]; Supplementary Table 3 ).
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The CRTh2 polymorphism rs533116 G > A associates with asthma severity in older females.
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