Sensitivities and Dependencies of <i>BRAF</i> Mutant Colorectal Cancer Cell Lines with or without <i>PIK3CA</i> Mutations for Discovery of Vulnerabilities with Therapeutic Potential.

Medicina (Kaunas) · 2022 · PMC9608248 · PMID 36295658

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closest p · 1.6× alpha

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boldest claim

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did not reach statistical significancep = 0.08so close (0.05 < p ≤ 0.1)

Specifically for colorectal cancer cell lines, BRAF mutant cell lines display also greater sensitivity to inhibitor WZ4003 compared to BRAF wild type colorectal cancer cell lines (mean IC50: 63.7 μM versus 132 μM), although, due to smaller numbers, this difference did not reach statistical significance ( p = 0.08). 4.

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