Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria.

Metabolites · 2022 · PMC9611790 · PMID 36295829

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Among these metabolites there was a clear trend of increased urinary abundance with increasing sTYR concentration; a relationship confirmed by the significant (FDR-adjusted p < 0.05) positive correlations observed between sTYR and all urine metabolites derived from phenylalanine, tyrosine, HPPA and HPLA with the exception of phenylalanine and HPPA-sulfate.

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