It of course changed p-values, as would be expected with a decrease in the number of independent observations, but only a small number of p-values that were nominally significant become slightly insignificant.
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Accounting for the clustering and nesting effects verifies most conclusions. Corrected analysis of: "Randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometabolic risk".
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