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Ubiquitin proteolysis of a CDK-related kinase regulates titan cell formation and virulence in the fungal pathogen Cryptococcus neoformans.

Nat Commun · 2022 · PMC9613880 · PMID 36302775

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Mice infected with the CRK1 OE strain also showed increased CD4 + T cells with higher Th1 cytokine production compared to mice infected with H99, but this increase did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.