Polyvalent Glycan Quantum Dots as a Multifunctional Tool for Revealing Thermodynamic, Kinetic, and Structural Details of Multivalent Lectin-Glycan Interactions.

Therefore, the k off ′ derived from competition-based kinetic studies must be treated with caution: it may not reflect the true disassociation rate under natural conditions. Such discrepancies can be quite significant, particularly for multivalent binding systems, where reassociation often occurs under natural conditions due to the close proximity of multiple binding pairs within the binding area.

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