Accumulation of misfolded SOD1 outlines distinct patterns of motor neuron pathology and death during disease progression in a SOD1^G93A mouse model of amyotrophic lateral sclerosis.

After coimmunostaining with anti‐mfSOD1 antibodies, we found that quantitative alterations in VAChT were observed in MNs exhibiting the type 2 and 3 phenotypes, whereas postsynaptic organization, visualized by NRG1 labeling, shows a tendency to be altered in the less severe phenotype and, more clearly, in early stages of disease (Figure 9A,B ); this change, however, did not reach statistical significance.

also in 111,027 other papers