Meta-analysis of epigenome-wide association studies of major depressive disorder.

Among the ten CpG sites significantly associated with self-reported antidepressant use reported from the Generation Scotland cohort 14 , two of them (cg03864397 annotated to CASP10 implicated in innate immune response, b = − 0.23, p = 0.03; cg26277237 annotated to KANK1 , b = 0.24, p = 0.03) were nominally significant in this meta-analysis ( p < 0.05) and with consistent direction in effect size (Supplementary Table 5 ).

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