Probands harboring rs363538 ‘CC’ genotype showed a trend for improvement in the trait scores (Fig. 1 e–h) with a significant impact on the IA score (Fig. 1 f).
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Kainate receptor subunit 1 (GRIK1) risk variants and GRIK1 deficiency were detected in the Indian ADHD probands.
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The sentences
The primary limitations of the present study are (a) the analysis of GRIK1 mRNA expression in only a limited number of samples and (b) marginally significant associations between the studied genetic variants and ADHD, as is evident from the close to significance p-values, low relative risk, and power of the association tests.