State-of-the-art review of the clinical research on menopause and hormone replacement therapy association with Parkinson's disease: What meta-analysis studies cannot tell us.

A more detailed assessment of the HRT formulations evidences a modest increased risk of PD in users of estrogen replacement therapy (ERT) in 2 cohort studies ( Simon et al., 2009 ; Liu et al., 2014 ) in contrast to 6 case–control studies ( Benedetti et al., 2001 ; Baldereschi et al., 2003 ; Currie et al., 2004 ; Ragonese et al., 2004 ; Gatto et al., 2014 ; Lundin et al., 2014 ) that showed a trend for a protective or no effect of ERT.

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