Prostaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway rats.

2e ; Dunnett’s multiple comparison test, p ≤ 0.0021, N = 10) with a highly significant trend of reducing IOP over the 12-month period (Fig. 2f , simple linear regression, p < 0.0001).

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2c ; Dunnett’s multiple comparison test, p = 0.01, N = 9) and there was a significant trend of decreasing IOP noted over the 12-month period (Fig. 2d ; simple linear regression, p = 0.0036) with a reduction in IOP of 21.88% from baseline to 12 months.

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