Furthermore, the TCA cycle intermediates succinate (−15.26 (−27.37, −3.15) pmoles∗mg tissue −1 , p = 0.007, Figure 6 B) and alpha-ketoglutarate (−5.51 (−11.45, −0.42) pmoles∗mg tissue −1 , p = 0.013, Figure 6 B) was significantly lower after dapagliflozin treatment, while citrate (−14.4604 (−28.4890, −0.4317) pmoles∗mg tissue −1 , p = 0.060, Figure 6 B) showed a trend towards lower levels after dapagliflozin treatment.
← all excerpts
Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism.
1
—
—