Feasibility of using P16 methylation as a cytologic marker for esophageal squamous cell carcinoma screening: A pilot study.

Cancer Med · 2022 · PMC9636512 · PMID 35352503

Europe PMC DOI

hedged sentences

0.2250

closest p · 4.5× alpha

0.2250

boldest claim

The sentences

did not reach statistical significancep = 0.225not close (p > 0.1)

The diagnostic performance of model II (AUC, 0.850), which incorporated P16 methylation in biopsy specimens, was better than the base model I and worse than model III, but these did not reach statistical significance ( p = 0.225 and p = 0.298, respectively) (Figure 3 ).

also in 111,027 other papers

an increasing trendno p-value reported

P16 methylation frequency in biopsy specimens showed an increasing trend with the increasing severity of histological diagnosis ( p for trend <0.001).

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.