FRET-FISH probes chromatin compaction at individual genomic loci in single cells.

Especially in the case of Magix , which is a non-escapee gene, the FRET-FISH score distribution of the inactive homologue was shifted towards higher score values indicating that this locus is associated with a more compacted chromatin state on the inactive chrX copy, although the difference between the two distributions did not reach statistical significance (Supplementary Fig. 8g–j ).

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