ATP production decreased to 28%, 83% and 81% of control values for lines SV20, GM00942 and GM21808, respectively, but did not change in line GM08399; the average for the four biological replicates was a 26% decrease, which did not reach statistical significance ( P =0.298, Fig. 1 D, left).
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Acute frataxin knockdown in induced pluripotent stem cell-derived cardiomyocytes activates a type I interferon response.
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