A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice.

Although insulin increased Akt (S473) phosphorylation by 77% in muscle of dams infused with sEVs from healthy pregnancies, this change failed to reach statistical significance ( n =6–8/group, P =0.15, Figure 3 F,G).

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