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Learn from failures and stay hopeful to GPR40, a GPCR target with robust efficacy, for therapy of metabolic disorders.

Front Pharmacol · 2022 · PMC9640913 · PMID 36386134

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showed a trendno p-value reported
In contrast, plasma glucagon levels only showed a trend of decrease in the whole gut gcg knockout mice and no change in distal gut gcg knockout mice compared with wild type mice, suggesting glucagon production is mainly produced from the pancreatic α-cell.

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