Sensitisation of cancer cells to radiotherapy by serine and glycine starvation.

In the majority of cell lines, we observed an expected increase in ROS exposure in response to radiation, which showed a trend to be further increased by SG starvation (Fig. 1d and Supplementary Fig.

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We also noted that as radiation dose increased, synergy generally decreased, an expected trend as when the radiation dose is more lethal there is less scope for the added benefit of starvation (Supplementary Fig.

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