A rotaxane-based platform for tailoring the pharmacokinetics of cancer-targeted radiotracers.

Chem Sci · 2022 · PMC9645377 · PMID 36519052

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showed a trendno p-value reported

55,64 β-CD also showed a trend towards renal enrichment, 55 which could explain the higher accumulation of [ 89 Zr]ZrFe-3 (the [4]rotaxane species that contains a β-CD unit) over [ 89 Zr]ZrFe-4 (the [3]rotaxane model ‘metabolite’ without β-CD) in the kidneys (12.0 ± 2.5 %ID g −1 [ n = 3] versus 5.4 ± 1.4 %ID g −1 , [ n = 4]).

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