Extract of <i>Mallotus oppositifolius</i> (Geiseler) Müll. Arg. increased prefrontal cortex dendritic spine density and serotonin and attenuated <i>para-</i>chlorophenylalanine-aggravated aggressive and depressive behaviors in mice.

Front Pharmacol · 2022 · PMC9649488 · PMID 36386158

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did not reach statistical significancep > 0.05actually significant

Higher doses of MOE (100, 300 mg/kg) slightly increased serotonin concentration in the PFC but did not reach statistical significance compared to the level in vehicle-treated mice ( p > 0.05; Figure 6A ).

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