GDNF Increases Inhibitory Synaptic Drive on Principal Neurons in the Hippocampus via Activation of the Ret Pathway.

The increase in mIPSC amplitudes in the GDNF-treated group, as analyzed by cell-based averages, did not reach statistical significance ( Figure 1 D) but was statistically significant according to cumulative probability curves ( p < 0.01 and D > 0.05), which, in contrast to sIPSCs, demonstrated that amplitudes below 30 pA were increased, while those over 30 pA were decreased in the magnitude.

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